Seneca: Vacation Rental By Owner

Showing 20 Of 94 Vacation Rentals
  • Property-1 Image 1
    House Select Dates for Price
    • 7 Bed
    • 5 Baths
    • (19)
    Seneca , SC

    Beautiful 2 story family friendly home. Located on a large secluded lot on Lake Keowee without any neighbors on either side of the house. It is just a short 10... ...more

  • Property-2 Image 1
    House Select Dates for Price
    • 4 Bed
    • 4 Baths
    • (10) Exceptional
    Seneca, SC

    4 Bedroom, 3.5 Bathroom Lakefront Home, Bought in August 2019, New to VRBO! Entire interior and exterior completely renovated with brand new paint. All... ...more

  • Property-3 Image 1
    House $415 / Nightly
    • 4 Bed
    • 3 Baths
    • (35)
    Seneca, SC

    Perfect waterfront vacation for the entire family. This 4 bedroom lake home sleeps 12 and offers all the essentials for a GREAT leisurely getaway. Our home... ...more

  • Property-4 Image 1
    House $425 / Nightly
    • 5 Bed
    • 4 Baths
    • (31)
    Seneca, SC

    The White House, 5 bedroom, 3 1/2 bath, Lake Hartwell home across the lake from Clemson University. Perfect for visiting that special Clemson student, football... ...more

  • Property-5 Image 1
    House $516 / Nightly
    • 5 Bed
    • 3 Baths
    • (16) Wonderful
    Seneca, SC

    A perfect lake front get-away on Lake Keowee in Seneca South Carolina at the end of a dead end street with no traffic! Relax by the pool over looking the lake,... ...more

  • Property-6 Image 1
    House Select Dates for Price
    • 3 Bed
    • 2 Baths
    • (1) Exceptional
    Seneca, SC

    This beautiful home has 3 bedrooms, 2 bathrooms and sleeps 8 comfortably.  A dynamic open floor plan allows everyone to be spread out yet be together whether it... ...more

  • Property-7 Image 1
    House Select Dates for Price
    • 4 Bed
    • 3 Baths
    • (11) Exceptional
    Seneca, SC

    Amazing lakefront retreat ready to host your entire family! This 4 bedroom house is furnished with all the comforts of your home and ready to help you relax.... ...more

  • Property-8 Image 1
    House $497 / Nightly
    • 4 Bed
    • 4 Baths
    • (53)
    Seneca, SC

    This new home sits on over an acre of land in a private lakefront setting at Lake Keowee in S.C. Large water views abound throughout the house. It has 4... ...more

  • Property-9 Image 1
    House Select Dates for Price
    • 5 Bed
    • 4 Baths
    • (21) Wonderful
    Seneca, SC

    This beautiful 2 story lake front home is set up for families to enjoy a relaxing time on the water or a quiet place to stay before catching a National Champion... ...more

  • Property-10 Image 1
    House $518 / Nightly
    • 4 Bed
    • 4 Baths
    • (40) Exceptional
    Seneca, SC

    At Wits Inn features a spacious, open floor plan with waterfront views from it's entire lakeside. Nestled in a mature wooded setting, highlights include a large... ...more

  • Property-11 Image 1
    House $776 / Nightly
    • 7 Bed
    • 7 Baths
    • (94)
    Seneca, SC

    Offered for the First Time ever! Great Location! 3 large levels, 7 BR/7BA, 8,475 Luxurious square feet and sleeps up to 20! HUGE Master Suite with 100" Projection... ...more

  • Property-12 Image 1
    Guest House Select Dates for Price
    • 2 Bed
    • 2 Baths
    • (2) Exceptional
    Seneca, SC

    Renting private walk out lower level of beautiful Lake front home. A dream lake house retreat: Walk-out level offers 2 bedrooms with attached 2 full baths, large... ...more

  • Property-13 Image 1
    House $325 / Nightly
    • 3 Bed
    • 3 Baths
    • (60)
    Seneca, SC

    Lake Front House with large master on main with king sized bed, walk-in closet and a full bath. Main level has a 25' vaulted ceiling with exposed beams, two-story... ...more

  • Property-14 Image 1
    Townhome $418 / Nightly
    • 3 Bed
    • 3 Baths
    • (15)
    Seneca, SC

    Whether you're here for a relaxing lakefront getaway or to cheer on the Tigers, this impressive Seneca vacation rental townhouse is the perfect choice for you!... ...more

  • Property-15 Image 1
    House $622 / Nightly
    • 5 Bed
    • 4 Baths
    • (29)
    The Cove: Executive Vacation Retreat... Seneca, SC

    If you've been looking for a quality rental home on Lake Hartwell, the executive-style retreat called The Cove is exactly what you've been searching for. As you... ...more

  • Property-16 Image 1
    House $602 / Nightly
    • 5 Bed
    • 5 Baths
    • (26) Exceptional
    Seneca, SC

    Bask in the beautiful views of Lake Keowee when you stay at this 5-bedroom, 5-bathroom vacation rental house in Seneca. This newly constructed home boasts 4,800... ...more

  • Property-17 Image 1
    House Select Dates for Price
    • 2 Bed
    • 2 Baths
    • (4) Exceptional
    Seneca, SC

    Enjoy lake living at its finest at this newly remodeled 2-bed, 2-bath vacation rental nestled amongst the trees of Seneca. Boasting glistening water views from... ...more

  • Property-18 Image 1
    House $377 / Nightly
    • 3 Bed
    • 3 Baths
    • (20)
    Seneca, SC

    Enjoy lake living at its best from this stunning vacation rental home right on Lake Keowee! With 3 bedrooms, 3 full bathrooms, and room for 10 guests, this rustic... ...more

  • Property-19 Image 1
    House $979 / Nightly
    • 9 Bed
    • 7 Baths
    • (41) Exceptional
    Seneca, SC

    If you’re looking to create life long memories, relax and unwind in a spacious and luxurious home, plus spend time on one of the most beautiful lakes in the... ...more

  • Property-20 Image 1
    House Select Dates for Price
    • 7 Bed
    • 6 Baths
    Seneca, SC

    3 Level 2800 Sq. Ft. Lake House On Lake Hartwell 3.5 Miles From Clemson Stadium Two Living Areas Two Separate Full Kitchens Two Sets of Washers and Dryers Large... ...more

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Vacation Rental Filters are an easy way to help you personalize your search to find the ideal rental in Seneca. Many accommodations in Seneca provide "Non Smoking Only", there are 120, or there are 105 of Vacation Rentals in Seneca with a "Children Welcome", there are also 94 with "Fishing", which is another great reason to visit Seneca.

We analyzed price data and rendered them in this graph, which shows vacation rental prices for the next twelve months in Seneca. The most expensive month of the next 12 months is in July, where prices hit an average of $310 a night. In June, prices will hit an average low of $295 per night.