Charming Cottage on Main St. in Historic St. Charles! Jetted Tub, 2 Fireplaces!!

Saint Charles, Missouri
$276 avg/night Minimum Stay 2 Nights
Bed 2

Bed

Bath 2

Bath

Home Private Vacation Home

Property Type

Sleep 8

Max Sleeps

Night 2 nights

Min Stay

'The Main Street Guest House' is a charming vacation rental home located right in the center of Historic Main Street in St. Charles, Missouri, the site of Missouri's first state capitol and starting point of the famous Lewis and Clark expedition. Located at #422 S. Main Street, this family friendly home has 3 newly remodeled levels, with a total of 6 beds (2 king, 4 twin), sleeping 8 people, as well as a luxurious master suite on the lower level that is perfect for couples.
The main floor of the house that walks directly out on to Main Street, has an open floor plan with comfortable living room with a large gas fireplace to snuggle up to, large flat screen TV with DVD player, full kitchen with high end cabinetry, refrigerator, stove/oven, microwave, dishwasher, and plenty of seating for meals with a great view out to the Missouri River. Huge rough sawn walnut support beams decorate the ceiling.
The 2nd floor bedroom suite, with 12' vaulted ceilings and large walnut support beams, sleeps 6 people. There is a large dormer overlooking Frontier Park, the old Train Depot and cabooses, and a beautiful view of the Missouri River flowing north that includes the custom built in king bed. Across the room there are 4 individual twin beds (2 sets of custom bunks) that allow for everyone to have their own comfy bed. Every bed comes with their own private lighting to make guests feel as comfortable as possible. There is also a giant flat screen clearly viewed from every bed for all to enjoy a movie night or game night on the Nintendo Wii. Also on this level is a full bathroom including a tiled walk in shower with dual shower-valves, and a sitting area with mirror for extra space to get ready, and the dormer on the front by the vanity overlooks the cobblestoned streets of Main.
The lower level includes the private master suite with a king bed, another flat screen TV, and full master bath including a large walk in tiled shower with two shower valves. Enjoy a huge Jacuzzi whirlpool tub heated with 136 gallon water capacity with Shiatzu massaging jets, and Chroma therapy lighted water. Two large fireplaces are also includes in the master suite. One fireplace is located next to the king bed and another in the master bathroom completely viewable from both the large walk in shower and whirlpool tub to add to your experience. Also on the lower level in a separate room, is a full laundry area for our guest to use.
The historic home has been 100% completely remodeled in 2013 and designed entirely with vacation renters in mind. All modern amenities are included such as two 80 gallon hot water heaters so you never run out of hot water, two separate heating and cooling systems so separate floors can control desired temperatures, cable TV, Wifi, Keurig coffee maker, and so much more. The location is excellent. Walk out your front door directly onto the cobblestone sidewalk along the one of the largest historic districts on the national registry. Countless shopping and dining options await you, all within walking distance (less than a half mile in either direction). The best part, most are unique businesses that you won't find anywhere else, like Braddens restaurant, Lewis and Clark restaurant, Winery of the Little Hills (great outdoor seating with fire pits located right across the street),The Mother-in-Law House restaurant 98ft away, The Hobbit Hole Antiques, Moss next door for some of the latest fashion, Trailhead Brewery, Grandmas Cookies a few doors down, Kat and Me, and countless others. A personal favorite with our family of four small of children is Riverside Sweets located only two doors down where visitors of all ages can enjoy some of the best ice cream, homemade candy and fudge, caramel apples, and walls of candy and collectibles to choose from. A few blocks north, Picasso's offers a great cup of coffee and some live music at times. Grab breakfast at The Bikestop Cafe and rent a bike for a peaceful ride on The Katy Trail just a few hundred feet from the home. Ameristar Casino is also located within a mile of the home just outside the Historic area for those looking for a little nightlife. Two major malls, Mid-Rivers Mall, and St. Louis Premium Outlet Mall, are located 10 minutes in either direction. Located on the other side of highway 70, The St. Charles Convention Center and Family Arena are located about five minutes from the guest house. A short 25 minute drive will get you to most St. Louis Attractions such as The Arch, The St. Louis Zoo, The Magic House, The City Museum, The Art Museum, Grants Farm, Busch Stadium, The Fox Theatre, The Peabody, The Art Museum, and so many other fun things to do and see. Spend the day seeing the sights of St. Louis and then head back to family friendly St. Charles, walk to dinner, and kick back and relax and visit with your loved ones at night. The home is located approximately 10-15 minutes from St. Louis Lambert Airport, with plenty of public and private transportation available. St. Peters Catholic church is just a short 1/4 mile stroll away, as well as the Main Street Church on North Main. SSM St. Joseph Health Center is also located within 1/4 mile for those needing a place to stay while visiting loved ones, or if health issues arise. With many fantastic festivities on Main Street and in Frontier Park for year round interest for all ages, there's always something new to experience when you stay at the Main Street Guest House! For some additional information, please go to for lots of great information and a calendar of upcoming events. Please feel free to call us at anytime. Hope to hear from you soon and thanks for your consideration!

Read More Expand
  • Feature Features
  • Map Map
  • School District Availability
  • Review Review

Feature Features

  • PETS

    No Pets Allowed
  • DINING

    Dining Table
  • SAFETY

    Carbon Monoxide Detector Installed (host Has Indicated There Is A Carbon Monoxide Detector On The Property) Deadbolt Lock Fire Extinguisher First Aid Kit Smoke Detector Installed (host Has Indicated There Is A Smoke Detector On The Property)
  • BEDROOM

    2 Bedrooms Bed Sheets Provided
  • GENERAL

    Unit Size: 1600 Sq Ft (149 Sq M)
  • KITCHEN

    Coffee/tea Maker Cookware/dishes/utensils Dishwasher Microwave Oven Refrigerator Spices Stovetop Toaster
  • LAUNDRY

    Laundry Facilities Near Laundromat Washing Machine And Dryer
  • PARKING

    Car Recommended Onsite Parking
  • INTERNET

    Free WiFi
  • OUTDOORS

    Garden Patio
  • BATHROOMS

    2 Bathrooms Hair Dryer Jetted Bathtub Shower Towels Provided
  • LANGS SPOKEN

    English
  • THINGS TO DO

    Birdwatching Nearby Casino Nearby Cycling Nearby Fishing Nearby Fitness Facilities Nearby Hiking Nearby Hiking/biking Trails Nearby Swimming Nearby Water Park Wildlife And Game Walks Nearby Winery Tours Nearby
  • ENTERTAINMENT

    Books DVD Player Games Video Games Video Library Smart TV With Cable/satellite Service
  • LIVING SPACES

    Fireplace Living Room
  • CLIMATE CONTROL

    Air Conditioning Heating
  • FAMILY FRIENDLY

    Children's Books Children's Toys Highchair Travel Crib
  • LOCATION HIGHLIGHTS

    In The City Center Near A Health Or Beauty Spa Near A Hospital Near A Zoo
  • SERVICES AND CONVENIENCES

    Iron/ironing Board
  • SUITABILITY/ACCESSIBILITY

    Smoke-free Property

CheckIn Check-in : 04:00 PM CheckOut Check-out : 11:00 AM
No Wheelchair No smoking No pets Children allowed
Occupancy Max occupancy : 8

Map Map

School District Availability

Review Review

  • Katherine H.

    Submitted Oct 14, 2025

    Stayed Oct 10, 2025

    Lovely house, clean and comfortable. Awesome location.

  • Carol M.

    Submitted Aug 28, 2025

    Stayed Aug 22, 2025

    It was wonderful. Furniture was not comfortable. Kitchen table was sticky and should seat at least 8

  • Maureen N.

    Submitted Aug 7, 2025

    Stayed Jul 29, 2025

    Beautiful property that was perfect for our family of 6! Loved that it was right across from the Katy Trail and conveniently located on Main Street next to shops and eateries! When we arrived, we were surprised by a cute basket of snacks and water in the fridge. All the kitchen supplies we needed to make a meal were also available! I had one question for the owners, and it was answered right away! Would highly recommend!!

  • Susan L.

    Submitted Jul 10, 2025

    Stayed Jul 7, 2025

    The house was perfect and my husband and I had a great getaway. The house was clean, kitchen was well stocked, and in a perfect location. We were able to walk around town and visited all the shops and restaurants. We would definitely stay again!

  • Eric S.

    Submitted Jun 10, 2025

    Stayed Jun 5, 2025

    The house was quite spacious for our needs. It was very nice and comfortable. Appreciate the care taken to restore this great property and decorated tastefully.

  • Richard B.

    Submitted May 18, 2025

    Stayed May 16, 2025

    What an amazing location! Right in the middle of the St Charles historic area! The house is very nice with lots of character and was perfect for our group of 6 friends! The hosts are very communicative without being overboard- would 100% stay here any chance I get! Thank you!!

  • Anna B.

    Submitted May 12, 2025

    Stayed May 9, 2025

    My family and I stayed there for my daughter’s college graduation. Walked the farmers market and across the street for dinner. It was quiet and we couldn’t have asked for a better place. Everyone loved it even my 80 year old auntie!

  • Anthony C.

    Submitted Apr 14, 2025

    Stayed Mar 31, 2025

    We were very happy with the home we stayed in. It was very clean and tidy and we appreciated the little things like snacks and waters when we arrived. We soon found out that St. Charles is definitely seasonal as many places were closed during the beginning of the week or being remodeled due to the off season. However we were still able to make the best of our vacation by heading towards downtown St Louis and other areas around St Charles. But just a heads up to those who stay on the actual Main St. Also the casino down the road isn’t nearly as nice as it used to be. Many machines not working and very smoky. But I would definitely recommend this home for a getaway for your family. Thank you for allowing us to stay in your cute home!

  • Felicia N.

    Submitted Mar 28, 2025

    Stayed Mar 22, 2025

    We loved our stay at the main st guest house! Perfect location and great property. We really enjoyed our stay!

  • Chris W.

    Submitted Mar 6, 2025

    Stayed Feb 14, 2025

    My four daughters, my granddaughter and I spent a three day weekend here in the middle of February. Even though the weather was wintry, we were just steps away from shopping and dining. We also had a spa day at the Ameristar hotel spa!. The house is historical and charming and perfectly designed to accommodate the six of us. A special thanks to the owner for answering my phone call on our arrival Valentine's evening after we had lockedd ourselves out! So appreciative.

  • Larry G.

    Submitted Feb 23, 2025

    Stayed Feb 21, 2025

    Beautiful property. Great location. Park and walk everywhere.

  • Jessica W.

    Submitted Jan 11, 2025

    Stayed Dec 25, 2024

    Such a beautiful home! We had a wonderful time over the holidays. The home was beautifully decorated. Highly recommended stay :)

  • Sunnie H.

    Submitted Oct 13, 2024

    Stayed Oct 11, 2024

    Absolutely perfect location for everything, we will be coming back.

  • Christine T.

    Submitted Oct 7, 2024

    Stayed Oct 4, 2024

    We came back to my hometown from Florida, with 3 other couples, to run the MO Cowbell race and enjoy downtown St. Charles. Overall experience was great, thanks to this wonderful VRBO!

  • Pati M.

    Submitted Sep 20, 2024

    Stayed Sep 16, 2024

    Location great. Enjoyed stay. Second year staying here and will book again next year

  • Becky B.

    Submitted Jul 22, 2024

    Stayed Jul 18, 2024

    We had never visited Saint Charles before and didn’t realize what a boon this location would be. While others were walking up and down the street looking for their cars, we were able to walk out our front door to all the shopping and dining we could handle. No need to drive anywhere. Communication with the host was easy. We will be back.

  • matt g.

    Submitted Jul 13, 2024

    Stayed Jul 10, 2024

    Super fun stay

  • Andrea B.

    Submitted Jun 20, 2024

    Stayed Jun 6, 2024

    We had our semi-annual girls trip here and we'd stayed here before. It is the perfect location for downtown shopping and dining. The cottage is cozy and has plenty of room to relax. We will be back.

  • Gary D.

    Submitted Jun 4, 2024

    Stayed May 31, 2024

    Can’t say enough good things about the great location of this property! It was great to walk out the door and have plenty of walkable food options and small shops to explore. The accommodations were also outstanding and very comfortable for the four adults in our group. The house was well stocked with more than we needed for our stay. We would highly recommend staying here!

  • Pamela H.

    Submitted May 23, 2024

    Stayed May 10, 2024

    We felt like we stepped back in time staying in a small cottage in the cobblestone street of Old St Charles.

Your dates are Available!

Total

Includes taxes and fees
$276+
View details