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22 Smilax Vine Road

Bluffton, SC 29910
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Acres2.21

Acres(Lot)

Set within the highly sought-after May River Forest neighborhood of Palmetto Bluff, 22 Smilax Vine Road presents a rare opportunity to create a custom Lowcountry retreat on an exceptional 2.21-acre homesite. Tucked away on a quiet cul-de-sac and surrounded by protected maritime forest, the homesite enjoys a remarkable sense of privacy while opening to beautiful views of the 16th fairway of the Jack Nicklaus Signature Golf Course. The generous acreage provides an inspiring canvas for a thoughtfully designed residence, with the golf course setting creating a picturesque backdrop and an opportunity to embrace expansive outdoor living. Surrounded by the distinctive landscape of May River Forest, the homesite captures the essence of Palmetto Bluff-where architecture and nature are thoughtfully intertwined. Life at Palmetto Bluff is defined by an extraordinary connection to nature and an unparalleled collection of amenities. Miles of walking and biking trails wind through forests and along waterways, while the community offers championship golf, equestrian facilities, fitness and wellness experiences, boating and river access, restaurants, shops, and an abundance of outdoor pursuits. From quiet mornings surrounded by nature to afternoons on the river and evenings gathered with family, Palmetto Bluff offers an enduring Lowcountry lifestyle unlike any other. With its combination of 2.21 acres, golf course views, mature natural surroundings, and coveted May River Forest location, 22 Smilax Vine Road represents an exceptional opportunity to create a one-of-a-kind Lowcountry legacy property-one thoughtfully designed for both the beauty of today and the generations to come.

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Detail Ic Property Details

Property Type : Land

Price : $2,195,000

AD Id : 91399406

MLS Id : 513047

Lot Size : 2.21 Acres(Lot)

County : Beaufort

Subdivision: Palmetto Bluff

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Feature Features

  • Lot Information

    Lot Dimensions: 2.21 Main Square Feet: 2.21 Acres

    Property Information

    Subdivision: PALMETTO BLUFF Source Property Type: Land MLS Area Minor: Palmetto Bluff Postal Code Plus 4: 2647 Zoning Description: Residential Property SubType: Unimproved Land

  • Listing Price Information

    Listing Price: $2195000 Cash, Conventional

  • Tax Information

    Parcel Number: R614 038 000 1656 0000 Tax Lot: 643

  • Homeowners Association Information
    Association Amenities: Tennis Court(s), Basketball Court, Marina, Clubhouse, Dog Park, Fitness Center, Playground, Pool, RV/Boat Storage, Spa/Hot Tub, Trail(s) Community Features: Pool

  • Location Information

    WaterSource: Public
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Nearby Home Value

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TBD Lost Oak Drive, Bluffton, SC, 29910 $2,500,000 -- -- -- 20.90 Acres(Lot)
TBD Lost Oaks Drive, Bluffton, SC, 29910 $2,500,000 -- -- -- 20 Acres(Lot)
51 Colleton River Drive, Bluffton, SC, 29910 $400,000 -- -- -- 0.13 Acre(Lot)
36 Magnolia Blossom Drive, Bluffton, SC, 29910 $720,000 -- -- -- 2.57 Acres(Lot)
53 Pointe South Trace, Bluffton, SC, 29910 $125,000 -- -- -- 0.25 Acre(Lot)
28 Ferebee Court, Bluffton, SC, 29910 $250,000 -- -- -- 0.48 Acre(Lot)
26 Ferebee Court, Bluffton, SC, 29910 $249,000 -- -- -- 0.37 Acre(Lot)
25 Martha Lane, Bluffton, SC, 29910 $1,150,000 -- -- -- 1.53 Acres(Lot)
87 Cumberland Drive, Bluffton, SC, 29910 $1,795,000 4 4 4,168 0.55 Acre(Lot)
25 Maiden Lane, Bluffton, SC, 29910 $450,000 -- -- -- 0.34 Acre(Lot)

©2026 REsides, Inc. All rights reserved. Certain information contained herein is derived from information which is the licensed property of, and copyrighted by, REsides, Inc”; and the REsides logo. We do not attempt to independently verify the currency, completeness, accuracy or authenticity of the data contained herein. It may be subject to transcription and transmission errors. Accordingly, the data is provided on an “as is” “as available” basis only and may not reflect all real estate activity in the market.

ByOwner last updated this listing 09/22/2026 @ 13:30

MLS: 513047 LISTED BY: Bryan Byrne, Palmetto Bluff Real Estate Co 800-501-7405 SOURCE: REsides (Hilton Head)

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